Behavioral and Pharmacological Validation of the Differential Reinforcement of Low-Rate Behavior Paradigm in Non-Human Primates

This study establishes the Differential Reinforcement of Low-Rate (DRL) task in cynomolgus macaques as a translationally relevant platform for screening antidepressant efficacy, demonstrating its ability to distinguish antidepressant-like effects across diverse drug classes while simultaneously identifying dose-limiting side effects like emesis that are not observable in rodent models.

Vanderlip, C. R., Dunn, S. R., Basile, J. L. + 3 more2026-03-19📄 animal behavior and cognition

Sex-Dependent Effects of Chronic Stress During Adolescence on Cognitive Bias and Functional Connectome in Young Adult Rats

Chronic restraint stress during adolescence induces sex-dependent negative cognitive biases and reduces specific functional connectivity in female rats, but not males, suggesting distinct neurobiological mechanisms underlying the heightened vulnerability of females to stress-related depression.

Dai, T., Jaeschke-Angi, L., Penrose-Menz, M. + 2 more2026-03-19📄 animal behavior and cognition

Machine learning of honey bee olfactory behavior identifies repellent odorants in free flying bees in the field

This study demonstrates that an iterative machine learning approach, which predicts aversive valence from chemical structure and refines models with behavioral data from both honey bees and Drosophila, successfully identified and validated potent repellent odorants capable of protecting free-flying honey bees from pesticide exposure in the field.

Kowalewski, J., Baer-Imhoof, B., Guda, T. + 4 more2026-03-18📄 animal behavior and cognition

Behavioral, hormonal, and chemical responses to seasonality in poison frogs with divergent reproductive strategies

This study reveals that poison frogs with divergent reproductive strategies cope with seasonal rainfall fluctuations primarily through behavioral flexibility in space and microhabitat use, while their hormonal profiles and chemical defenses remain largely decoupled from these environmental changes.

Serrano-Rojas, S. J., Pasukonis, A., Gonzalez, M. + 10 more2026-03-18📄 animal behavior and cognition

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

This study reveals that sleep deprivation impairs prefrontal information processing by upregulating BDNF-TrkB signaling, which downregulates the chloride exporter KCC2 to disrupt chloride homeostasis and weaken GABAergic inhibition, a mechanism distinct from but additive to allopregnanolone-mediated deficits.

Frau, R., Concas, L., Braccagni, G. + 16 more2026-03-18📄 animal behavior and cognition

TALE and Hox Transcription Factors Control Adult Behaviors in Zebrafish

This study demonstrates that mutations in individual members of the TALE and Hox transcription factor families in adult zebrafish cause both shared stress-related behavioral abnormalities and distinct, mutation-specific deficits in coping, social interaction, learning, and locomotion, revealing how genetic variation within these families differentially contributes to mental health disorder vulnerabilities.

Adkins, A., Glowinski, K., Kim, Y.-I. + 4 more2026-03-18📄 animal behavior and cognition

Chronoecological interactions: Temporal niche-switching by black-striped mice after agonistic food competition with a dominant sympatric mouse species

Through direct video monitoring in the wild, this study reveals that subordinate black-striped mice (*Apodemus agrarius*) avoid agonistic competition with dominant yellow-necked mice (*Apodemus flavicollis*) for a novel food source by switching their foraging activity from nocturnal to diurnal, thereby achieving temporal niche segregation and safe resource access.

Stryjek, R., d'Isa, R., Parsons, M. H. + 5 more2026-03-17📄 animal behavior and cognition

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

This study demonstrates that while low adiponectin levels correlate with poorer mental health in non-obese women with PCOS, adiponectin deficiency alone does not exacerbate anxiety-like behaviors in a lean PCOS-like mouse model, highlighting the complex interplay between adipokines, androgens, and mental health in the syndrome.

Samad, M. b., Ek, J., Kataoka, J. + 5 more2026-03-17📄 animal behavior and cognition

TracktorLive: an integrated real-time object tracking and response system

TracktorLive is an open-source, modular Python package that democratizes real-time object tracking and automated response systems by utilizing traditional computer vision and concurrent processing to eliminate hardware dependencies and steep learning curves, thereby offering a highly accurate and accessible solution for diverse scientific applications.

Minasandra, P., Sridhar, V. H., Roche, D. G. + 1 more2026-03-16📄 animal behavior and cognition